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7-Ketolithocholic acid

CAS No. 4651-67-6

7-Ketolithocholic acid( 3α-Hydroxy-7-oxo-5β-cholanic acid )

Catalog No. M26545 CAS No. 4651-67-6

7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    7-Ketolithocholic acid
  • Note
    Research use only, not for human use.
  • Brief Description
    7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.
  • Description
    7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) can be absorbed and suppresses endogenous bile acid production and biliary cholesterol secretion.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    3α-Hydroxy-7-oxo-5β-cholanic acid
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    PRMT5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4651-67-6
  • Formula Weight
    390.56
  • Molecular Formula
    C24H38O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (256.04 mM)
  • SMILES
    C[C@H](CCC(O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])C(C[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Christopher R. Smith, et al. Abstract LB003: Fragment based discovery of MRTX9768, a synthetic lethal-based inhibitor designed to bind the PRMT5-MTA complex and selectively target MTAP/CDKN2A-deleted tumors. Cancer Res 1 July 2021; 81 (13_Supplement): LB003.
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